mTOR and Autophagy- Interview with James Clement

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• Supercentenarians are the rare individuals who have made it to the age of 110 and beyond. At any given time, there are only 50 to 80 supercentenarians in the entire world. In the U.S., an estimated 120,000 people make it to 100, but only 20 of them make it to 110
• What sets them apart is that, up until the ages of 105 to 108, they’ve maintained the health of someone in their 70s and 80s. They have no age-related diseases, and typically die from sudden onset immune failure
• In many respects, supercentenarians age normally, while the rest of us age at an accelerated rate. The basis of the book, “The Switch: Ignite Your Metabolism With Intermittent Fasting, Protein Cycling, and Keto,” is essentially how to normalize your aging rate, thus allowing you to optimize your life span
• Cyclically activating and deactivating the mTOR pathway to intermittently trigger autophagy is a key element that will increase your longevity. Time-restricted eating and other fasting regimens accomplish this. Fasted exercise can further boost results
• NAD+ is one of the most important longevity molecules that we know of. NAD+ is a coenzyme needed by longevity-related enzymes called sirtuins. It’s also required for DNA repair, but levels plummet with age, necessitating ways to boost NAD+ levels. Strategies include time-restricted eating, fasted exercise and supplementation

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